Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[2,3-d][1,3]thiazin-4-one 3. Acylation of the a...

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Bibliographic Details
Published in:Molecules
Main Authors: Gad, Emad M., Nafie, Mohamed S., Eltamany, Elsayed H., Hammad, Magdy S. A. G., Barakat, Assem, Boraei, Ahmed T. A.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321303/
https://ncbi.nlm.nih.gov/pubmed/32481682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25112523
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