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Model Substrate/Inactivation Reactions for MoaA and Ribonucleotide Reductases: Loss of Bromo, Chloro, or Tosylate Groups from C2 of 1,5-Dideoxyhomoribofuranoses upon Generation of an α-Oxy Radical at C3 †

We report studies on radical-initiated fragmentations of model 1,5-dideoxyhomoribofuranose derivatives with bromo, chloro, and tosyloxy substituents on C2. The effects of stereochemical inversion at C2 were probed with the corresponding arabino epimers. In all cases, the elimination of bromide, chlo...

詳細記述

保存先:
書誌詳細
出版年:Molecules
主要な著者: Wnuk, Stanislaw F., Mudgal, Mukesh M., Nowak, Ireneusz, Robins, Morris J.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321198/
https://ncbi.nlm.nih.gov/pubmed/32486052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25112539
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