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Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment

The combination of folinic acid, 5-fluorouracil, oxaliplatin and/or irinotecan (FOLFOXIRI) is the standard of care for metastatic colorectal cancer (CRC). This strategy inhibits tumor growth but provokes drug resistance and serious side effects. We aimed to improve FOLFOXIRI by optimization of the d...

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Bibliographic Details
Published in:Molecules
Main Authors: Zoetemelk, Marloes, Ramzy, George M., Rausch, Magdalena, Nowak-Sliwinska, Patrycja
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321123/
https://ncbi.nlm.nih.gov/pubmed/32512790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25112614
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