Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

Despite growing evidence suggesting that spinal microglia play an important role in the molecular mechanism underlying experimental neuropathic pain (NP) in male rodents, evidence regarding the sex-dependent role of these microglia in NP is insufficient. In this study, we evaluated the effects of mi...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Saika, Fumihiro, Matsuzaki, Shinsuke, Kobayashi, Daichi, Ideguchi, Yuya, Nakamura, Tomoe Y., Kishioka, Shiroh, Kiguchi, Norikazu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318895/
https://ncbi.nlm.nih.gov/pubmed/32636748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00925
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