Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

Studies demonstrate that small molecule targeting of atypical protein kinase C (aPKC) may provide an effective means to control vascular permeability, prevent edema, and reduce inflammation providing novel and important alternatives to anti-VEGF therapies for certain blinding eye diseases. Based on...

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Publicado no:Bioorg Med Chem
Main Authors: Liu, Xuwen, Wilson, Michael W., Liu, Kun, Lee, Pil, Yeomans, Larisa, Hagen, Susan E., Lin, Cheng-Mao, Wen, Bo, Sun, Duxin, White, Andrew D., Showalter, Hollis D., Antonetti, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318885/
https://ncbi.nlm.nih.gov/pubmed/32327351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115480
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