Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure

Recent studies suggest CNNM2 (cyclin M2) to be part of the long-sought basolateral Mg(2+) extruder at the renal distal convoluted tubule, or its regulator. In the present study, we explore structural features and ligand-binding capacities of the Bateman module of CNNM2 (residues 429–584), an intrace...

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Pubblicato in:Biochem J
Autori principali: Corral-Rodríguez, María Ángeles, Stuiver, Marchel, Abascal-Palacios, Guillermo, Diercks, Tammo, Oyenarte, Iker, Ereño-Orbea, June, Ibáñez de Opakua, Alain, Blanco, Francisco J., Alessio, José Antonio Encinar, Spiwok, Vojtêch, Terashima, Hiroyuki, Accardi, Alessio, Müller, Dominik, Martínez-Cruz, Luis Alfonso
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318797/
https://ncbi.nlm.nih.gov/pubmed/25184538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140409
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