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Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure
Recent studies suggest CNNM2 (cyclin M2) to be part of the long-sought basolateral Mg(2+) extruder at the renal distal convoluted tubule, or its regulator. In the present study, we explore structural features and ligand-binding capacities of the Bateman module of CNNM2 (residues 429–584), an intrace...
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| 發表在: | Biochem J |
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| Main Authors: | , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7318797/ https://ncbi.nlm.nih.gov/pubmed/25184538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140409 |
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