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Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions
Chimeric antigen receptor modified T cells (CAR-T) have yielded impressive clinical outcomes in treating hematopoietic malignancies. However, relapses have occurred in a substantial number of patients and limited the development of CAR-T therapy. Most underlying reasons for these relapses can be att...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7318076/ https://ncbi.nlm.nih.gov/pubmed/32636832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01046 |
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