Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis

Staphylococcus aureus osteomyelitis is a debilitating infection of bone. Treatment of osteomyelitis is impaired by the propensity of invading bacteria to induce pathological bone remodeling that may limit antibiotic penetration to the infectious focus. The nonsteroidal anti-inflammatory drug difluni...

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發表在:Antimicrob Agents Chemother
Main Authors: Spoonmore, Thomas J., Ford, Caleb A., Curry, Jacob M., Guelcher, Scott A., Cassat, James E.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Clinical Therapeutics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318050/
https://ncbi.nlm.nih.gov/pubmed/32340992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00182-20
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