Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 pat...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Wattanakul, Thanaporn, Ogutu, Bernhards, Kabanywanyi, Abdunoor M., Asante, Kwaku-Poku, Oduro, Abraham, Adjei, Alex, Sie, Ali, Sevene, Esperanca, Macete, Eusebio, Compaore, Guillaume, Valea, Innocent, Osei, Isaac, Winterberg, Markus, Gyapong, Margaret, Adjuik, Martin, Abdulla, Salim, Owusu-Agyei, Seth, White, Nicholas J., Day, Nicholas P. J., Tinto, Halidou, Baiden, Rita, Binka, Fred, Tarning, Joel
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2020
Ämnen:
Clinical Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318010/
https://ncbi.nlm.nih.gov/pubmed/32312783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01848-19
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