Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 pat...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wattanakul, Thanaporn, Ogutu, Bernhards, Kabanywanyi, Abdunoor M., Asante, Kwaku-Poku, Oduro, Abraham, Adjei, Alex, Sie, Ali, Sevene, Esperanca, Macete, Eusebio, Compaore, Guillaume, Valea, Innocent, Osei, Isaac, Winterberg, Markus, Gyapong, Margaret, Adjuik, Martin, Abdulla, Salim, Owusu-Agyei, Seth, White, Nicholas J., Day, Nicholas P. J., Tinto, Halidou, Baiden, Rita, Binka, Fred, Tarning, Joel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318010/
https://ncbi.nlm.nih.gov/pubmed/32312783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01848-19
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