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A Photochemical Organocatalytic Strategy for the α‐Alkylation of Ketones by using Radicals

Reported herein is a visible‐light‐mediated radical approach to the α‐alkylation of ketones. This method exploits the ability of a nucleophilic organocatalyst to generate radicals upon S(N)2‐based activation of alkyl halides and blue light irradiation. The resulting open‐shell intermediates are then...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Spinnato, Davide, Schweitzer‐Chaput, Bertrand, Goti, Giulio, Ošeka, Maksim, Melchiorre, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317845/
https://ncbi.nlm.nih.gov/pubmed/32053279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201915814
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