On the localization of the cleavage site in human alpha‐2‐antiplasmin, involved in the generation of the non‐plasminogen binding form

BACKGROUND: Alpha‐2‐antiplasmin (α2AP) is the main natural inhibitor of plasmin. The C‐terminus of α2AP is crucial for the initial interaction with plasmin(ogen) and the rapid inhibitory mechanism. Approximately 35% of circulating α2AP has lost its C‐terminus (non‐plasminogen binding α2AP/NPB‐α2AP)...

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Détails bibliographiques
Publié dans:J Thromb Haemost
Auteurs principaux: Abdul, Shiraazkhan, Dekkers, Dick H. W., Ariëns, Robert A. S., Leebeek, Frank W. G., Rijken, Dingeman C., Uitte de Willige, Shirley
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
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FIBRINOLYSIS
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317795/
https://ncbi.nlm.nih.gov/pubmed/32034861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14761
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