Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin

Around 70% of circulating alpha-2-antiplasmin (α2AP), the main natural plasmin inhibitor, is N-terminally cleaved between residues Pro12 and Asn13 by antiplasmin-cleaving enzyme. This converts native Met-α2AP into the more potent fibrinolysis inhibitor Asn-α2AP. The Arg6Trp (R6W) polymorphism affect...

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Vydáno v:PLoS One
Hlavní autoři: Abdul, Shiraazkhan, Peeters, Miet, Brouwers, Els, Malfliet, Joyce J. M. C., Leebeek, Frank W. G., Declerck, Paul J., Rijken, Dingeman C., Uitte de Willige, Shirley
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933735/
https://ncbi.nlm.nih.gov/pubmed/29723259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196911
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