Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells

PURPOSE: To investigate the role of protein misfolding in retinal pigment epithelial (RPE) cell dysfunction, the effects of R345W-Fibulin-3 expression on RPE cell phenotype were studied. METHODS: Primary RPE cells were cultured to confluence on Transwells and infected with lentivirus constructs to e...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Zhou, Mi, Weber, Sarah R., Zhao, Yuanjun, Chen, Han, Barber, Alistair J., Grillo, Stephanie L., Wills, Carson A., Wang, Hong Gang, Hulleman, John D., Sundstrom, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317295/
https://ncbi.nlm.nih.gov/pubmed/32637411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00469
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