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After Nf1 loss in Schwann cells, inflammation drives neurofibroma formation

Plexiform neurofibromas (PNF) are peripheral nerve tumors caused by bi-allelic loss of NF1 in the Schwann cell (SC) lineage. PNF are common in individuals with Neurofibromatosis type I (NF1) and can cause significant patient morbidity, spurring research into potential therapies. Immune cells are rar...

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Bibliografske podrobnosti
izdano v:Neurooncol Adv
Main Authors: Fletcher, Jonathan S, Pundavela, Jay, Ratner, Nancy
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317060/
https://ncbi.nlm.nih.gov/pubmed/32642730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz045
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