Next-Generation Manufacturing Protocols Enriching T(SCM) CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients

Chimeric antigen receptor (CAR) T cell expansion and persistence emerged as key efficacy determinants in cancer patients. These features are typical of early-memory T cells, which can be enriched with specific manufacturing procedures, providing signal one and signal two in the proper steric conform...

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Vydáno v:Front Immunol
Hlavní autoři: Arcangeli, Silvia, Falcone, Laura, Camisa, Barbara, De Girardi, Federica, Biondi, Marta, Giglio, Fabio, Ciceri, Fabio, Bonini, Chiara, Bondanza, Attilio, Casucci, Monica
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317024/
https://ncbi.nlm.nih.gov/pubmed/32636841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01217
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