Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia

TP53 aberrations reportedly predict favorable responses to decitabine (DAC) in acute myeloid leukemia (AML). We evaluated clinical features and outcomes associated with chromosome 17p loss or TP53 gene mutations in older, unfit DAC-treated AML patients in a phase II trial. Of 178 patients, 25 had lo...

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Detalhes bibliográficos
Publicado no:Ann Hematol
Main Authors: Becker, Heiko, Pfeifer, Dietmar, Ihorst, Gabriele, Pantic, Milena, Wehrle, Julius, Rüter, Björn H., Bullinger, Lars, Hackanson, Björn, Germing, Ulrich, Kuendgen, Andrea, Platzbecker, Uwe, Döhner, Konstanze, Ganser, Arnold, Hagemeijer, Anne, Wijermans, Pierre W., Döhner, Hartmut, Duyster, Justus, Lübbert, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316846/
https://ncbi.nlm.nih.gov/pubmed/32504186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-020-04082-7
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