Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Mitochondrial dysfunction leads to osteoarthritis (OA) and disc degeneration. Hypoxia inducible factor-1α (HIF-1α) mediated mitophagy has a protective role in several diseases. However, the underlying mechanism of HIF-1α mediated mitophagy in OA remains largely unknown. This current study was perfor...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Hu, Sunli, Zhang, Chunwu, Ni, Libin, Huang, Chongan, Chen, Dingwen, Shi, Keqing, Jin, Haiming, Zhang, Kairui, Li, Yao, Xie, Ling, Fang, Mingqiao, Xiang, Guangheng, Wang, Xiangyang, Xiao, Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316774/
https://ncbi.nlm.nih.gov/pubmed/32587244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2680-0
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