NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

Non-T cell activation linker (NTAL) is a lipid raft-membrane protein expressed by normal and leukemic cells and involved in cell signaling. In acute promyelocytic leukemia (APL), NTAL depletion from lipid rafts decreases cell viability through regulation of the Akt/PI3K pathway. The role of NTAL in...

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Publicat a:Sci Rep
Autors principals: Thomé, Carolina Hassibe, Ferreira, Germano Aguiar, Pereira-Martins, Diego Antonio, dos Santos, Guilherme Augusto, Ortiz, César Alexander, de Souza, Lucas Eduardo Botelho, Sobral, Lays Martins, Silva, Cleide Lúcia Araújo, Scheucher, Priscila Santos, Gil, Cristiane Damas, Leopoldino, Andréia Machado, Silveira, Douglas R. A., Coelho-Silva, Juan L., Traina, Fabíola, Koury, Luisa C., Melo, Raul A. M., Bittencourt, Rosane, Pagnano, Katia, Pasquini, Ricardo, Nunes, Elenaide C., Fagundes, Evandro M., Gloria, Ana Beatriz F., Kerbauy, Fábio Rodrigues, Chauffaille, Maria de Lourdes, Keating, Armand, Tallman, Martin S., Ribeiro, Raul C., Dillon, Richard, Ganser, Arnold, Löwenberg, Bob, Valk, Peter, Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, Faça, Vitor Marcel, Rego, Eduardo M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316767/
https://ncbi.nlm.nih.gov/pubmed/32587277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66223-2
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