Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation

BACKGROUND: Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored. METHODS: Tamoxifen inducible α-SMA promoter C...

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Publicado no:Mucosal Immunol
Main Authors: Zhao, Shuai, Dejanovic, Dina, Yao, Peng, Bhilocha, Shardul, Sadler, Tammy, Schirbel, Anja, West, Gail, Doyon, Genevieve, Lopez, Rocio, Mao, Ren, Kurada, Satya, El Ouali, Sara, Grassl, Guntram, Fox, Paul L., Cruise, Michael, Worthley, Daniel L., de la Motte, Carol, Fiocchi, Claudio, Rieder, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316631/
https://ncbi.nlm.nih.gov/pubmed/32020030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-0259-9
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