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Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment
The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20...
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| Pubblicato in: | Semin Cancer Biol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316602/ https://ncbi.nlm.nih.gov/pubmed/31883910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2019.12.013 |
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