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Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

[Image: see text] Monobodies are small engineered binding proteins that, upon expression in cells, can inhibit signaling of cytosolic oncoproteins with outstanding selectivity. Efficacy may be further increased by inducing degradation of monobody targets through fusion to the von Hippel–Lindau (VHL)...

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Bibliografische gegevens
Gepubliceerd in:ACS Chem Biol
Hoofdauteurs: Schmit, Nadine Eliane, Neopane, Katyayanee, Hantschel, Oliver
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2019
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316569/
https://ncbi.nlm.nih.gov/pubmed/31025848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00113
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