Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its own recept...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shi, Zhigang, Pelletier, Nicole E, Wong, Jennifer, Li, Baoxin, Sdrulla, Andrei D, Madden, Christopher J, Marks, Daniel L, Brooks, Virginia L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316512/
https://ncbi.nlm.nih.gov/pubmed/32538782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55357
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