Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans

Seasonal influenza A viruses of humans evolve rapidly due to strong selection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface protein. Based on mouse transmission experiments, a proposed mechanism for immune evasion consists of increased avidity to host cell...

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Udgivet i:PLoS Comput Biol
Main Authors: Saad-Roy, Chadi M., Arinaminpathy, Nimalan, Wingreen, Ned S., Levin, Simon A., Akey, Joshua M., Grenfell, Bryan T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316228/
https://ncbi.nlm.nih.gov/pubmed/32584807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007892
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