Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition

It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive component. Infected cells upregulate the CD47 “don’t eat me” sign...

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Publicat a:mBio
Autors principals: Tal, Michal Caspi, Torrez Dulgeroff, Laughing Bear, Myers, Lara, Cham, Lamin B., Mayer-Barber, Katrin D., Bohrer, Andrea C., Castro, Ehydel, Yiu, Ying Ying, Lopez Angel, Cesar, Pham, Ed, Carmody, Aaron B., Messer, Ronald J., Gars, Eric, Kortmann, Jens, Markovic, Maxim, Hasenkrug, Michaela, Peterson, Karin E., Winkler, Clayton W., Woods, Tyson A., Hansen, Paige, Galloway, Sarah, Wagh, Dhananjay, Fram, Benjamin J., Nguyen, Thai, Corey, Daniel, Kalluru, Raja Sab, Banaei, Niaz, Rajadas, Jayakumar, Monack, Denise M., Ahmed, Aijaz, Sahoo, Debashis, Davis, Mark M., Glenn, Jeffrey S., Adomati, Tom, Lang, Karl S., Weissman, Irving L., Hasenkrug, Kim J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315125/
https://ncbi.nlm.nih.gov/pubmed/32576678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01293-20
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