Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies

Backbone macrocyclic structures are often found in diverse bioactive peptides and contribute to greater conformational rigidity, peptidase resistance, and potential membrane permeability compared to their linear counterparts. Therefore, such peptide scaffolds are an attractive platform for drug-disc...

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Vydáno v:Front Chem
Hlavní autoři: Shinbara, Koki, Liu, Wenyu, van Neer, Renier Herman Pieter, Katoh, Takayuki, Suga, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314982/
https://ncbi.nlm.nih.gov/pubmed/32626683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00447
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