Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies

Backbone macrocyclic structures are often found in diverse bioactive peptides and contribute to greater conformational rigidity, peptidase resistance, and potential membrane permeability compared to their linear counterparts. Therefore, such peptide scaffolds are an attractive platform for drug-disc...

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Sparad:
Bibliografiska uppgifter
I publikationen:Front Chem
Huvudupphovsmän: Shinbara, Koki, Liu, Wenyu, van Neer, Renier Herman Pieter, Katoh, Takayuki, Suga, Hiroaki
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314982/
https://ncbi.nlm.nih.gov/pubmed/32626683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00447
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