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Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-κB/STAT3-regulated proteins

5-Fluorouracil (5-FU) is one of the most effective drugs for the treatment of colorectal cancer (CRC). However, there is an urgent need in reducing its systemic side effects and chemoresistance to make 5-FU-based chemotherapy more effective and less toxic in the treatment of CRC. Here, enalapril, a...

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Podrobná bibliografie
Vydáno v:Cell Death Dis
Hlavní autoři: Yang, Yushan, Ma, Lulu, Xu, Yiming, Liu, Yun, Li, Wenya, Cai, Jianchun, Zhang, Yiyao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314775/
https://ncbi.nlm.nih.gov/pubmed/32581212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2675-x
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