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Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation
MacroD1 is an enzyme that hydrolyzes protein mono-ADP-ribosylation. However, the key catalytic residues of MacroD1 in these biochemical reactions remain elusive. Here, we present the crystal structure of MacroD1 in a complex with ADP-ribose (ADPR). The β5-α10-loop functions as a switch loop to media...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier B.V.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7313891/ https://ncbi.nlm.nih.gov/pubmed/32683309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102899 |
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