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X-ray Structure-Based Chemoinformatic Analysis Identifies Promiscuous Ligands Binding to Proteins from Different Classes with Varying Shapes

(1) Background: Compounds with multitarget activity are of interest in basic research to explore molecular foundations of promiscuous binding and in drug discovery as agents eliciting polypharmacological effects. Our study has aimed to systematically identify compounds that form complexes with prote...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Feldmann, Christian, Bajorath, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312685/
https://ncbi.nlm.nih.gov/pubmed/32471121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21113782
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