Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites

Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative to other cytochr...

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Bibliografiske detaljer
Udgivet i:Front Cell Infect Microbiol
Main Authors: McPhillie, Martin J., Zhou, Ying, Hickman, Mark R., Gordon, James A., Weber, Christopher R., Li, Qigui, Lee, Patty J., Amporndanai, Kangsa, Johnson, Rachel M., Darby, Heather, Woods, Stuart, Li, Zhu-hong, Priestley, Richard S., Ristroph, Kurt D., Biering, Scott B., El Bissati, Kamal, Hwang, Seungmin, Hakim, Farida Esaa, Dovgin, Sarah M., Lykins, Joseph D., Roberts, Lucy, Hargrave, Kerrie, Cong, Hua, Sinai, Anthony P., Muench, Stephen P., Dubey, Jitender P., Prud'homme, Robert K., Lorenzi, Hernan A., Biagini, Giancarlo A., Moreno, Silvia N., Roberts, Craig W., Antonyuk, Svetlana V., Fishwick, Colin W. G., McLeod, Rima
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Cellular and Infection Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311950/
https://ncbi.nlm.nih.gov/pubmed/32626661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.00203
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