Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites

Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative to other cytochr...

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Опубликовано в: :Front Cell Infect Microbiol
Главные авторы: McPhillie, Martin J., Zhou, Ying, Hickman, Mark R., Gordon, James A., Weber, Christopher R., Li, Qigui, Lee, Patty J., Amporndanai, Kangsa, Johnson, Rachel M., Darby, Heather, Woods, Stuart, Li, Zhu-hong, Priestley, Richard S., Ristroph, Kurt D., Biering, Scott B., El Bissati, Kamal, Hwang, Seungmin, Hakim, Farida Esaa, Dovgin, Sarah M., Lykins, Joseph D., Roberts, Lucy, Hargrave, Kerrie, Cong, Hua, Sinai, Anthony P., Muench, Stephen P., Dubey, Jitender P., Prud'homme, Robert K., Lorenzi, Hernan A., Biagini, Giancarlo A., Moreno, Silvia N., Roberts, Craig W., Antonyuk, Svetlana V., Fishwick, Colin W. G., McLeod, Rima
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Cellular and Infection Microbiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311950/
https://ncbi.nlm.nih.gov/pubmed/32626661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.00203
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