Histone Deacetylase Inhibitors to Overcome Resistance to Targeted and Immuno Therapy in Metastatic Melanoma

Therapies that target oncogenes and immune checkpoint molecules constitute a major group of treatments for metastatic melanoma. A mutation in BRAF (BRAF V600E) affects various signaling pathways, including mitogen activated protein kinase (MAPK) and PI3K/AKT/mammalian target of rapamycin (mTOR) in m...

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Udgivet i:Front Cell Dev Biol
Main Authors: Yeon, Minjeong, Kim, Youngmi, Jung, Hyun Suk, Jeoung, Dooil
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311641/
https://ncbi.nlm.nih.gov/pubmed/32626712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00486
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