Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abno...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Assaraf, Eran, Blecher, Ronen, Heinemann-Yerushalmi, Lia, Krief, Sharon, Carmel Vinestock, Ron, Biton, Inbal E., Brumfeld, Vlad, Rotkopf, Ron, Avisar, Erez, Agar, Gabriel, Zelzer, Elazar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311488/
https://ncbi.nlm.nih.gov/pubmed/32576830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16971-6
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