Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abno...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Assaraf, Eran, Blecher, Ronen, Heinemann-Yerushalmi, Lia, Krief, Sharon, Carmel Vinestock, Ron, Biton, Inbal E., Brumfeld, Vlad, Rotkopf, Ron, Avisar, Erez, Agar, Gabriel, Zelzer, Elazar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311488/
https://ncbi.nlm.nih.gov/pubmed/32576830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16971-6
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