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Ultra-large chemical libraries for the discovery of high-affinity peptide binders
High-diversity genetically-encoded combinatorial libraries (10(8)−10(13) members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10(6) compounds by screening. Here we show tha...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7311396/ https://ncbi.nlm.nih.gov/pubmed/32576815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16920-3 |
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