DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapy

BACKGROUND: Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown in colon cancer. However, biologic significance and relevance to I/O in metastatic clear cell RCC (ccRCC) are unknown...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Ged, Yasser, Chaim, Joshua L, DiNatale, Renzo G, Knezevic, Andrea, Kotecha, Ritesh R, Carlo, Maria I, Lee, Chung-Han, Foster, Ashley, Feldman, Darren R, Teo, Min Yuen, Iyer, Gopakumar, Chan, Timothy, Patil, Sujata, Motzer, Robert J, Hakimi, A Ari, Voss, Martin H
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Clinical/Translational Cancer Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311069/
https://ncbi.nlm.nih.gov/pubmed/32571992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000230
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