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Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

Protein prenylation is a posttranslational modification involving the attachment of a C15 or C20 isoprenoid group to a cysteine residue near the C-terminus of the target substrate by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I), respectively. Both of the...

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Pubblicato in:Biochemistry
Autori principali: Ashok, Sudhat, Hildebrandt, Emily R., Ruiz, Colby S., Hardgrove, Daniel S., Coreno, David W., Schmidt, Walter K., Hougland, James L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310673/
https://ncbi.nlm.nih.gov/pubmed/32125828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00081
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