Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

A mechanistic understanding of the SARS-CoV-2 viral replication cycle is essential to develop new therapies for the COVID-19 global health crisis. In this study, we show that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid phase separation (LLPS) with the viral genome, and pr...

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Gepubliceerd in:bioRxiv
Hoofdauteurs: Iserman, Christiane, Roden, Christine, Boerneke, Mark, Sealfon, Rachel, McLaughlin, Grace, Jungreis, Irwin, Park, Chris, Boppana, Avinash, Fritch, Ethan, Hou, Yixuan J., Theesfeld, Chandra, Troyanskaya, Olga G, Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin, Gladfelter, Amy S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310621/
https://ncbi.nlm.nih.gov/pubmed/32587965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.11.147199
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