Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic elements under physiological buffer conditions and condensation is enhanced at human body temperatures (33°C and 37°C) and redu...

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書誌詳細
出版年:Mol Cell
主要な著者: Iserman, Christiane, Roden, Christine A., Boerneke, Mark A., Sealfon, Rachel S.G., McLaughlin, Grace A., Jungreis, Irwin, Fritch, Ethan J., Hou, Yixuan J., Ekena, Joanne, Weidmann, Chase A., Theesfeld, Chandra L., Kellis, Manolis, Troyanskaya, Olga G., Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin M., Gladfelter, Amy S.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier Inc. 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691212/
https://ncbi.nlm.nih.gov/pubmed/33290746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.041
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