Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic elements under physiological buffer conditions and condensation is enhanced at human body temperatures (33°C and 37°C) and redu...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Iserman, Christiane, Roden, Christine A., Boerneke, Mark A., Sealfon, Rachel S.G., McLaughlin, Grace A., Jungreis, Irwin, Fritch, Ethan J., Hou, Yixuan J., Ekena, Joanne, Weidmann, Chase A., Theesfeld, Chandra L., Kellis, Manolis, Troyanskaya, Olga G., Baric, Ralph S., Sheahan, Timothy P., Weeks, Kevin M., Gladfelter, Amy S.
Format: Artigo
Langue:Inglês
Publié: Elsevier Inc. 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691212/
https://ncbi.nlm.nih.gov/pubmed/33290746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.041
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