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Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

BACKGROUND: Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of the HIV-2 protease (PR2) in bound and unbound forms exhibit structural asymmet...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Mol Cell Biol
Main Authors: Laville, Pierre, Fartek, Sandrine, Cerisier, Natacha, Flatters, Delphine, Petitjean, Michel, Regad, Leslie
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310402/
https://ncbi.nlm.nih.gov/pubmed/32576133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00290-1
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