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Exploration of the effect of sequence variations located inside the binding pocket of HIV-1 and HIV-2 proteases
HIV-2 protease (PR2) is naturally resistant to most FDA (Food and Drug Administration)-approved HIV-1 protease inhibitors (PIs), a major antiretroviral class. In this study, we compared the PR1 and PR2 binding pockets extracted from structures complexed with 12 ligands. The comparison of PR1 and PR2...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893546/ https://ncbi.nlm.nih.gov/pubmed/29636521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24124-5 |
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