An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly

[Image: see text] An economical synthesis of lamivudine was developed by employing a new method to establish the stereochemistry about the heterocyclic oxathiolane ring. Toward this end, an inexpensive and readily accessible lactic acid derivative served the dual purpose of activating the carbohydra...

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Detalhes bibliográficos
Publicado no:Org Process Res Dev
Main Authors: Snead, David R., McQuade, D. Tyler, Ahmad, Saeed, Krack, Rudy, Stringham, Rodger W., Burns, Justina M., Abdiaj, Irini, Gopalsamuthiram, Vijayagopal, Nelson, Ryan C., Gupton, B. Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7309434/
https://ncbi.nlm.nih.gov/pubmed/32587454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.oprd.0c00083
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