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Modeling hyperosmotic blood–brain barrier opening within human tissue-engineered in vitro brain microvessels
As the majority of therapeutic agents do not cross the blood–brain barrier (BBB), transient BBB opening (BBBO) is one strategy to enable delivery into the brain for effective treatment of CNS disease. Intra-arterial infusion of the hyperosmotic agent mannitol reversibly opens the BBB; however, wides...
में बचाया:
| में प्रकाशित: | J Cereb Blood Flow Metab |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
SAGE Publications
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308510/ https://ncbi.nlm.nih.gov/pubmed/31394959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19867980 |
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