Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway. The aim of the curre...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pediatr
Egile Nagusiak: Cwiklinska, Magdalena, Czogala, Malgorzata, Kwiecinska, Kinga, Madetko-Talowska, Anna, Szafarz, Malgorzata, Pawinska, Katarzyna, Wieczorek, Aleksandra, Klekawka, Tomasz, Rej, Magdalena, Stepien, Konrad, Halubiec, Przemyslaw, Lazarczyk, Agnieszka, Miklusiak, Karol, Bik-Multanowski, Miroslaw, Balwierz, Walentyna, Skoczen, Szymon
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Pediatrics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308427/
https://ncbi.nlm.nih.gov/pubmed/32612964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2020.00307
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