Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway. The aim of the curre...

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Udgivet i:Front Pediatr
Main Authors: Cwiklinska, Magdalena, Czogala, Malgorzata, Kwiecinska, Kinga, Madetko-Talowska, Anna, Szafarz, Malgorzata, Pawinska, Katarzyna, Wieczorek, Aleksandra, Klekawka, Tomasz, Rej, Magdalena, Stepien, Konrad, Halubiec, Przemyslaw, Lazarczyk, Agnieszka, Miklusiak, Karol, Bik-Multanowski, Miroslaw, Balwierz, Walentyna, Skoczen, Szymon
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pediatrics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308427/
https://ncbi.nlm.nih.gov/pubmed/32612964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2020.00307
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