Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell

FZR1/CDH1 is an activator of Anaphase promoting complex/Cyclosome (APC/C), best known for its role as E3 ubiquitin ligase that drives the cell cycle. APC/C activity is regulated by CDK-mediated phosphorylation of FZR1 during mitotic cell cycle. Although the critical role of FZR1 phosphorylation has...

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Publicado no:Sci Rep
Main Authors: Tanno, Nobuhiro, Kuninaka, Shinji, Fujimura, Sayoko, Takemoto, Kazumasa, Okamura, Kaho, Takeda, Naoki, Araki, Kimi, Araki, Masatake, Saya, Hideyuki, Ishiguro, Kei-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308413/
https://ncbi.nlm.nih.gov/pubmed/32572094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67116-0
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