Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH

Nonalcoholic fatty liver disease (NAFLD) and its evolution to inflammatory steatohepatitis (NASH) are the most common causes of chronic liver damage and transplantation that are reaching epidemic proportions due to the upraising incidence of metabolic syndrome, obesity, and diabetes. Currently, ther...

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Udgivet i:Cell Death Differ
Main Authors: Tan, Mingjun, Mosaoa, Rami, Graham, Garrett T., Kasprzyk-Pawelec, Anna, Gadre, Shreyas, Parasido, Erika, Catalina-Rodriguez, Olga, Foley, Patricia, Giaccone, Giuseppe, Cheema, Amrita, Kallakury, Bhaskar, Albanese, Chris, Yi, Chunling, Avantaggiati, Maria Laura
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308387/
https://ncbi.nlm.nih.gov/pubmed/31959914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0491-6
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