Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIP(L) heterodimer

Pharmacological targeting via small molecule-based chemical probes has recently acquired an emerging importance as a valuable tool to delineate molecular mechanisms. Induction of apoptosis via CD95/Fas and TRAIL-R1/2 is triggered by the formation of the death-inducing signaling complex (DISC). Caspa...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Hillert, Laura K., Ivanisenko, Nikita V., Busse, Denise, Espe, Johannes, König, Corinna, Peltek, Sergey E., Kolchanov, Nikolai A., Ivanisenko, Vladimir A., Lavrik, Inna N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308354/
https://ncbi.nlm.nih.gov/pubmed/31959913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0489-0
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