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Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIP(L) heterodimer
Pharmacological targeting via small molecule-based chemical probes has recently acquired an emerging importance as a valuable tool to delineate molecular mechanisms. Induction of apoptosis via CD95/Fas and TRAIL-R1/2 is triggered by the formation of the death-inducing signaling complex (DISC). Caspa...
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| Pubblicato in: | Cell Death Differ |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308354/ https://ncbi.nlm.nih.gov/pubmed/31959913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0489-0 |
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